articleChemical ReviewsJan 12, 2026Closed access

Base Metal Catalysis in Nitrene Transfer Reactions

Indian Institute of Science Education and Research Pune

PubMed
Indexed incrossrefpubmed

Abstract

Leveraging base metal catalysis to transform small organic molecules by forging X-N bonds (X = C, N, P, S) through nitrene transfer reactions (NTRs) renders a robust and sustainable paradigm shift for preparing valuable amine building blocks. Over the last four decades, 3d metal-catalyzed NTRs have received significant attention in the field of organic synthesis. This review will thoroughly discuss the manipulation of various complexes of base metals, such as Mn, Fe, Co, Ni, and Cu, to control the reaction pathways for X-N bond formation using different nitrene precursors. This review will encompass exemplary, pioneering, and pertinent synthesis in this area and will comprehensively elucidate the mechanistic…

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