articleChinese MedicineJan 13, 2026GOLD OA

Supramolecular self-assembly in Traditional Chinese Medicine: molecular mechanisms, material basis of decoction efficacy, compatibility interpretation, and biomedical applications

YWYinan WangQXQiang XiaoCLCan LiuWHWenjun HeXRXinning Ren

Hunan University of Traditional Chinese Medicine

PubMed
Indexed incrossrefdoajpubmed

Abstract

Traditional Chinese Medicine (TCM), characterized by multi-component and multi-target pharmacological effects, boasts millennia of clinical application. The complexity of its pharmacological material basis extends beyond individual chemical components to include physical structures formed among constituents. Supramolecular chemistry offers a new perspective for elucidating this basis. This review systematically summarizes recent advances in supramolecular self-assemblies within TCM, focusing on molecular formation mechanisms, key chemical component characteristics driving assembly, their roles in decoctions, and the supramolecular basis for "efficacy enhancement and toxicity reduction" in compatibility theory.…

Citation impact

5
total citations
FWCI
39.77
Percentile
100%
References
145
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Authors

9

Topics & keywords

Topics
Keywords
  • Supramolecular chemistry
  • Compatibility (geochemistry)
  • Traditional Chinese medicine
  • Supramolecular assembly
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