articleFrontiers in MicrobiologyJan 13, 2026GOLD OA

Molecular resistance mechanisms to newly approved antibiotics (2017–2025) in WHO priority pathogens

MSM. SartoriSTS. ToppoELE. Lavezzo

University of Padua

PubMed
Indexed incrossrefdoajpubmed

Abstract

The relentless rise of antimicrobial resistance (AMR) poses a critical threat to global public health, rendering once-effective therapies obsolete. In response, several novel antibiotics have been developed in recent years. This review systematically summarizes the molecular resistance mechanisms that World Health Organization (WHO) priority bacterial pathogens have already deployed against the 15 new antibiotics approved between 2017 and 2025, including β-lactam/β-lactamase inhibitors (cefiderocol, ceftazidime-avibactam, meropenem-vaborbactam), tetracycline derivatives (eravacycline, omadacycline), a pleuromutilin (lefamulin), an aminoglycoside (plazomicin), and a fluoroquinolone (delafloxacin). We detail how…

Citation impact

5
total citations
FWCI
40.50
Percentile
100%
References
209
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Authors

3

Topics & keywords

Topics
Keywords
  • Antibiotic resistance
  • Antibiotics
  • Efflux
  • Antimicrobial
  • Drug resistance
  • Tetracycline
  • Human health
UN Sustainable Development Goals
  • Partnerships for the goals
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