Neutrophils as critical orchestrators of chronic inflammation
Rega Institute for Medical Research · KU Leuven
Abstract
Neutrophils are the first key effector innate immune cells recruited toward inflammatory sites. Through the release of neutrophilic extracellular traps (NETs), the production of reactive oxygen species (ROS), degranulation and phagocytosis, neutrophils play a central role in the rapid elimination of invading pathogens. Recently, increasing attention has been given to the role of neutrophils in chronic inflammation, challenging the dichotomy between innate and adaptive immune responses. In chronic inflammatory conditions, neutrophils generally display a hyperinflammatory phenotype via dysregulated pathogen defense mechanisms. Excessive neutrophil activation may result in aberrant cell death, uncontrolled…
Citation impact
- FWCI
- 93.75
- Percentile
- 100%
- References
- 304
Authors
6- KTKaat Torfs
Rega Institute for Medical Research, KU Leuven
- GVGaël Vermeersch
Rega Institute for Medical Research, KU Leuven
- MGMieke Gouwy
Rega Institute for Medical Research, KU Leuven
- TDTimothy Devos
Rega Institute for Medical Research, KU Leuven
- PPPaul ProostCorresponding
Rega Institute for Medical Research
Topics & keywords
- Inflammation
- Neutrophil extracellular traps
- Innate immune system
- Immune system
- Context (archaeology)
- Proinflammatory cytokine
- Acquired immune system
- Degranulation