Bio-inspired supramolecular hydrogel inhibits ferroptosis to accelerate diabetic wound healing

Ferroptosis significantly compromises diabetic wound healing and represents a promising therapeutic target for clinical intervention. Baicalein (Bai), a natural flavonoid, has been considered to own ferroptosis-regulating properties, while the underlying mechanisms remain understood.

The study aims to investigate potential mechanisms by which Bai inhibits ferroptosis in endothelial cells and validate the therapeutic efficacy of Bai-loaded hydrogel on diabetic wounds.