Immunoinformatics-based design and evaluation of a multi-epitope vaccine against Vibrio fluvialis
University of Central Punjab · University of Ioannina · +3 more institutions
Abstract
Vibrio fluvialis is an emerging foodborne pathogen causing gastroenteritis and extraintestinal infections, representing a significant public health concern due to rising antimicrobial resistance and the absence of an approved vaccine. This study aimed to design a multi-epitope subunit vaccine against V. fluvialis using immunoinformatics and a standard multi-epitope vaccine design pipeline. Two surface-exposed immunogenic membrane proteins, ATP-dependent zinc metalloprotease FtsH and lytic murein transglycosylase F, were selected as antigenic targets. Ten epitopes, including four MHC class I, four MHC class II, and two B-cell epitopes, were predicted and assembled into a 246 amino acid vaccine construct. The…
Citation impact
- FWCI
- 60.14
- Percentile
- 100%
- References
- 83
Authors
10Topics & keywords
- In silico
- Antigenicity
- Vibrio cholerae
- Immunogenicity
- Epitope
- Population
- Reverse vaccinology
- Antigen