Cancer cachexia: molecular basis and therapeutic advances

The dynamic interplay between neoplastic cells and the host has been increasingly recognized as important players in the pathogenesis of cancer cachexia, a syndrome affecting ~50-80% of cancer patients with various incidences of different types of malignancies. Despite its prevalence, a comprehensive understanding of cancer cachexia progression, with a holistic view at the cross-organismal, cellular and molecular levels, remains elusive. In this review, we undertake an in-depth exploration of the relevant target organs and their regulatory roles in cancer cachexia, with a particular focus on macroenvironmental interactions via various organismal crosstalk axes. Moreover, we highlight how systemic metabolic…

• NN
  National Natural Science Foundation of China

  Awards: 82192890, 82192891, 82203318
• CP
  China Postdoctoral Science Foundation
• NS
  Natural Science Foundation of Chongqing

  Awards: CSTB2022NSCQ, CSTB2023NSCQ, CSTB2024NSCQ, CSTB2022NSCQ-MSX0880, CSTB2023NSCQ-LZX0156
• CS
  Centre Scientifique et Technique du Bâtiment
• NK
  National Key Research and Development Program of China

  Award: 2023YFC3402100