articleBMJJan 12, 2026BRONZE OA

Starting right: aligning eligibility and treatment assignment at time zero when emulating a target trial

Leiden University · Brigham and Women's Hospital · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

This article provides methodological guidance when emulating a target trial with longitudinal observational data by showing how to align eligibility criteria and treatment assignment at the start of follow-up to prevent design induced biases, such as immortal time and selection bias.

Citation impact

10
total citations
FWCI
213.21
Percentile
100%
References
48
Too recent for citation history.

Authors

5

Topics & keywords

Keywords
  • Observational study
  • Selection (genetic algorithm)
  • Zero (linguistics)
  • Longitudinal data
  • Research design
No related works found for this paper.

Funding