Detection of clonal hematopoiesis of indeterminate potential via genome or exome sequencing underestimates disease associations
Vanderbilt University Medical Center · Queen's University · +1 more institution
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Abstract
Epidemiology studies underestimate the strength of the association between clonal hematopoiesis and disease due to false negatives from shallow, whole-genome sequencing versus deep targeted sequencing.
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Authors
10Topics & keywords
Topics
Keywords
- Exome sequencing
- Disease
- Exome
- Genome
- Haematopoiesis
- Indeterminate
- Whole genome sequencing
- Genome-wide association study
UN Sustainable Development Goals
- Zero hunger
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Funding
- ANArthritis National Research FoundationAward: 1288083
- NINational Institutes of HealthAwards: R01HD074711, P50GM115305, DP5 OD029586, S10OD025092, R01NS032830, S10OD017985,S10RR025141,S10OD025092,UL1TR002243,UL1TR000445,UL1RR024975,U01HG004798,R01NS032830,RC2GM092618,P50GM115305,U01HG006378,U19HL065962,R01HD074711,DP5 OD029586,R01 AG088657,T32 GM007347, R01 AG088657, U01HG004798, U19HL065962, U01HG006378, S10OD017985, UL1RR024975, T32 GM007347, S10RR025141, RC2GM092618, UL1TR002243, UL1TR000445