Inter-individual variability of neurotransmitter receptor and transporter density in the human brain

Hansen, Justine Y.; Tuisku, Jouni; Johansson, Jarkko; Chang, Zeyu; McGinnity, Colm J.; Beliveau, Vincent; Guimond, Synthia; Ganz, Melanie; Nørgaard, Martin; Galovic, Marian; Bezgin, Gleb; Cox, Sylvia M. L.; Hietala, J.; Leyton, Marco; Kobayashi, Eliane; Rosa-Neto, Pedro; Funck, Thomas; Palomero-Gallagher, Nicola; Knudsen, Gitte M.; Pd, Marsden; Hammers, Alexander; Nummenmaa, Lauri; Tuominen, Lauri; Misic, Bratislav

doi:10.1007/s00429-025-03069-2

articleBrain Structure and FunctionJan 13, 2026HYBRID OA

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain

JYJustine Y. Hansen JTJouni Tuisku JJJarkko Johansson ZCZeyu Chang CJColm J. McGinnity

Montreal Neurological Institute and Hospital · McGill University · +25 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Neurotransmitter receptors guide the propagation of signals between brain regions. Mapping receptor distributions in the brain is therefore necessary for understanding how neurotransmitter systems mediate the link between brain structure and function. Normative receptor density can be estimated using group averages from Positron Emission Tomography (PET) imaging. However, the generalizability and reliability of group-average receptor maps depends on the inter-individual variability of receptor density, which is currently unknown. Here we collect group standard deviation brain maps of PET-estimated protein abundance for 12 different neurotransmitter receptors and transporters across 7 neurotransmitter systems,…

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Keywords

Neurotransmitter receptor
Neurotransmitter
Human brain
Receptor
Generalizability theory
Neurotransmitter systems

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