Impact of positive surgical margins on biochemical recurrence and metastases after radical prostatectomy
Canisius-Wilhelmina Ziekenhuis · Prostate Cancer UK · +5 more institutions
Abstract
To evaluate the impact of the presence, extent and location of positive surgical margins (PSMs) on the risk of biochemical recurrence (BCR) and metastases in a nationwide cohort of patients who underwent radical prostatectomy (RP) and had 5 years of follow-up.
All patients diagnosed with prostate cancer in the Netherlands between October 2015 and April 2016 who underwent RP were included in a prospective cohort. Data on these patients from the Netherlands Cancer Registry and the PALGA pathology registry were analysed. BCR was defined as a prostate-specific antigen (PSA) level ≥0.1 ng/mL >28 days after RP. Exclusion criteria were (neo)adjuvant treatment, pN1 disease, and salvage therapy initiated at PSA
Citation impact
- FWCI
- 63.43
- Percentile
- 99%
- References
- 36
Authors
11- JVJoost van DrumptCorresponding
Canisius-Wilhelmina Ziekenhuis, Prostate Cancer UK
- DBD.J.H. Baas
Canisius-Wilhelmina Ziekenhuis, Prostate Cancer UK
- KAKatja Aben
Radboud University Nijmegen, Radboud University Medical Center, Netherlands Comprehensive Cancer Organisation
- AGArno G.J.L.H. van Leenders
Erasmus MC Cancer Institute
- LKLambertus Kiemeney
Radboud University Nijmegen, Radboud University Medical Center
Topics & keywords
- Biochemical recurrence
- Prostatectomy
- Prostate cancer
- Limiting
- Cancer recurrence
- Radiation therapy
- Surgical margin
- Reduced inequalities