Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes
Brigham and Women's Hospital · Harvard University · +30 more institutions
Abstract
The human metabolome reflects complex metabolic states affected by genetic and environmental factors. However, metabolites associated with type 2 diabetes (T2D) risk and their determinants remain insufficiently characterized. Here we integrated blood metabolomic, genomic and lifestyle data from up to 23,634 initially T2D-free participants from ten cohorts. Of 469 metabolites examined, 235 were associated with incident T2D during up to 26 years of follow-up, including 67 associations not previously reported across bile acid, lipid, carnitine, urea cycle and arginine/proline, glycine and histidine pathways. Further genetic analyses linked these metabolites to signaling pathways and clinical traits central to T2D…
Citation impact
- FWCI
- 72.68
- Percentile
- 100%
- References
- 118
Authors
52- JLJun LiCorresponding
Brigham and Women's Hospital, Harvard University
- JHJie Hu
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital
- HYHuan Yun
Harvard University
- ZMZhendong Mei
Brigham and Women's Hospital, Harvard University
- XWXingyan Wang
Harvard University
Topics & keywords
- Type 2 diabetes
- Metabolome
- Obesity
- Insulin resistance
- Diabetes mellitus
- Urea cycle
- Metabolomics
- Metabolic syndrome
Funding
- AHAmerican Heart AssociationAward: 23POST1020455
- NNNovo Nordisk FondenAward: NNF24OC0095435
- NINational Institute on AgingAward: R01AG085320
- NHNational Heart, Lung, and Blood InstituteAwards: R01HL153178, K24HL152440, R01HL060712, R01HL136266, R01HL060712; R01HL170904
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAwards: R01DK081572, R01DK134672, R01DK119268; R01DK126698; U01DK140761; R01DK120870, U01DK140761, R00DK122128