Advances and Perspectives in Curcumin Regulation of Systemic Metabolism: A Focus on Multi-Organ Mechanisms

Curcumin, a natural polyphenol derived from turmeric, functions as a potent exogenous antioxidant and exhibits a range of benefits in the prevention and management of metabolic diseases. Despite its extremely low systemic bioavailability, curcumin demonstrates significant bioactivity in vivo, a phenomenon likely attributable to its accumulation in the intestines and subsequent modulation of systemic oxidative stress and inflammation. This article systematically reviews the comprehensive regulatory effects of curcumin on systemic metabolic networks-including glucose metabolism, amino acid metabolism, lipid metabolism, and mitochondrial metabolism-and explores their molecular basis, particularly how curcumin…

• NN
  National Natural Science Foundation of China

  Awards: 82173815, 82170850, 81872873
• CS
  Central South University
• FR
  Fundamental Research Funds for the Central Universities
• FR
  Fundamental Research Funds for Central Universities of the Central South University

  Award: 1053320230334