articleEP EuropaceJan 9, 2026GREEN OA

Impact of saline irrigation on haemolysis, silent cerebral lesion incidence, thermal dynamics, and bubble formation in pulsed field ablation with a variable-loop circular catheter

DZDongtao ZhouMLMengmeng LiZSZhigang SongCJChenxi JiangWWWei Wang

Beijing Anzhen Hospital

PubMed
Indexed incrossrefpubmed

Abstract

AIMS: Though pulsed-field ablation (PFA) has demonstrated an excellent safety profile in reducing collateral injury to the oesophagus and phrenic nerve, it is still associated with specific effects, including electrode heating, haemolysis, and electrolysis due to excessive energy dispersion. This study aims to assess whether saline irrigation during PFA application could mitigate these risks. METHODS AND RESULTS: To comprehensively evaluate the effect of irrigation with the variable-loop circular catheter (VLCC), the following experiments were performed: (i) ex-vivo potato model: to evaluate the lesion depth, bubble formation, and thermal effects in different irrigation regimens; (ii) in vitro blood pool and…

Citation impact

4
total citations
FWCI
60.50
Percentile
99%
References
37
Too recent for citation history.

Authors

25

Topics & keywords

Topics
Keywords
  • Bubble
  • Liquid bubble
  • Ablation
  • Saline
  • Catheter
  • Thermal ablation
  • Irrigation
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