Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure

Excess adiposity is a major risk factor for hypertension and heart disease. Brown fat is associated with protection from cardiovascular pathology, but whether this relationship is causal remains unknown. In this work, we investigate the role of mouse beige fat, as a model of human inducible brown fat, in adipocyte-vascular cross-talk. Using adipocyte-specific Prdm16 knockout mice with a loss of beige adipocyte identity, we discovered marked remodeling of perivascular adipose tissue, increased vascular reactivity, and elevated blood pressure. We show that the circulating enzyme QSOX1 is derepressed in Prdm16 -deficient adipocytes, and deletion of Qsox1 in Prdm16 conditional knockout mice prevented vascular…

• CH
  Charles H. Revson Foundation

  Award: 23-22
• DF
  Deutsche Forschungsgemeinschaft

  Award: KO 6368/1-1
• FL
  Fondation Leducq

  Award: 21CVD01
• NH
  National Heart, Lung, and Blood Institute

  Award: RO1HL152195
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: RC2DK129961
• NC
  National Center for Advancing Translational Sciences

  Awards: UL1TR004419, UL1TR001866