articleCellJan 16, 2026HYBRID OA

Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy

XGXize GaoXLXiangrong LiuNWNanxing WangCCChengqian CuiWLWeiming Liu

Tsinghua University · National Clinical Research Center for Digestive Diseases · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The rapid accessibility of calvarial immune cells to the brain, in principle, may offer transformative opportunities for overcoming drug delivery barriers in central nervous system (CNS) disorders. Here, we hijacked calvarial immune cells using drug-loaded nanoparticles (NPs) and leveraged their unique migration mechanism through skull-meninges microchannels to bypass the blood-brain barrier (BBB) for CNS drug delivery. We constructed NP-loaded immune cells in situ via intracalvariosseous (ICO) injection, validated their prompt migration in response to CNS perturbation, and targeted therapeutic delivery to CNS lesions. Compared with conventional delivery approaches, this strategy achieved promising therapeutic…

Citation impact

8
total citations
FWCI
109.96
Percentile
100%
References
49
Too recent for citation history.

Authors

19

Topics & keywords

Topics
Keywords
  • Immune system
  • Drug delivery
  • Central nervous system
  • Clinical trial
  • Drug
  • Targeted drug delivery
  • Mechanism (biology)
  • Immunotherapy
UN Sustainable Development Goals
  • Good health and well-being
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