Multianalyte nano-biosensor diagnostics: advances through microfluidic and AI integration

Recent advances in nano-biosensors are reshaping clinical diagnostics by enabling multiplexed biomarker detection with high sensitivity and precision. This mini-review examines both the opportunities and challenges in translating nano-biosensor technologies toward clinically relevant point-of-care (PoC) and wearable devices. We emphasize the integration of multiplexing strategies with microfluidic platforms and adaptive artificial intelligence (AI) algorithms, which together enable real-time, high-throughput, and personalized health monitoring. Electrochemical and optical transduction approaches for multi-biomarker diagnostics are discussed, along with the role of microfluidic integration in enhancing sensor…

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