Don’t judge an implant by its cover: how the foreign body response and fibrotic capsule might be harnessed for good

Dickenson, Mary E.; Oakes, Robert S.; Morris, Aaron H.

doi:10.1038/s44385-025-00053-7

articlenpj Biomedical Innovations.Jan 16, 2026DIAMOND OA

Don’t judge an implant by its cover: how the foreign body response and fibrotic capsule might be harnessed for good

MEMary E. Dickenson RSRobert S. Oakes AHAaron H. Morris

University of Michigan · VA Maryland Health Care System · +2 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Biomaterials are widely used, yet when implanted, they elicit a complex reaction from the host called the foreign body response (FBR). Although the FBR is typically viewed as a deleterious response to implants, many potential benefits of the FBR have recently been identified. This review highlights the variety of ways that the FBR has been harnessed for positive outcomes, including tissue engineering and disease monitoring.

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Topics & keywords

Topics

Keywords

Foreign body
Host response
Implant
Capsule
Inflammatory response
Foreign Bodies

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