articleAIJan 16, 2026GOLD OA

Explainable Multi-Modal Medical Image Analysis Through Dual-Stream Multi-Feature Fusion and Class-Specific Selection

University of Naples Federico II · Institute for High Performance Computing and Networking

Indexed incrossrefdoaj

Abstract

Effective and transparent medical diagnosis relies on accurate and interpretable classification of medical images across multiple modalities. This paper introduces an explainable multi-modal image analysis framework based on a dual-stream architecture that fuses handcrafted descriptors with deep features extracted from a custom MobileNet. Handcrafted descriptors include frequency-domain and texture features, while deep features are summarized using 26 statistical metrics to enhance interpretability. In the fusion stage, complementary features are combined at both the feature and decision levels. Decision-level integration combines calibrated soft voting, weighted voting, and stacking ensembles with optimized…

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4
total citations
FWCI
73.88
Percentile
99%
References
32
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3

Topics & keywords

Keywords
  • Discriminative model
  • Pattern recognition (psychology)
  • Feature selection
  • Benchmark (surveying)
  • Random forest
  • Feature (linguistics)
  • Image (mathematics)
  • Selection (genetic algorithm)
UN Sustainable Development Goals
  • Reduced inequalities
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