Organoids for disease modeling and treatment: state-of-the-art
Weifang Medical University · Shandong University · +6 more institutions
Abstract
The emergence of organoids has received widespread attention for faithful recapitulation of physiological and pathological conditions, together with overcoming the major bottleneck of extrapolating laboratory findings from model systems to human organs. Organoid technologies are one of the most revolutionary breakthroughs in the fields of regenerative medicine and biomedical research. These three-dimensional (3D) micro-organ models are derived from stem cells and tissue derivatives, and can highly simulate the structure and function of parental organs, which thus open up unprecedented avenues for understanding organogenesis, disease modeling, drug screening and individualized therapeutics. In this review, we…
Citation impact
- FWCI
- 69.53
- Percentile
- 100%
- References
- 179
Authors
10Topics & keywords
- Organoid
- Regenerative medicine
- Biobank
- Precision medicine
- Disease
- Personalized medicine
- Function (biology)
- Multidisciplinary approach