Molecular Gardening for Neuroinflammation via Nose‐to‐Brain Delivery: A Ca 2+ Responsive DNA Nanocage‐Hydrogel System With Neuron Targeting and STING Inhibiting
Sichuan University · Sichuan Provincial Library · +6 more institutions
Abstract
ABSTRACT Intranasal administration offers a rapid and non‐invasive route to deliver therapeutics directly from the nasal cavity into the brain for treating central nervous system (CNS) disorders. However, its efficacy is hampered by limited CNS targeting efficiency and rapid clearance in the nasal microenvironment. Here, a Ca 2+ responsive alginate hydrogel drug delivery system (namely SA@T SCC ) encapsulating a STING inhibitor within a neuronal targeting aptamer‐modified DNA nanocage for intranasal administration is developed. SA@T SCC demonstrates enhanced nasal retention, sustained release, and efficient transport of cargo into the CNS, leading to robust accumulation in the brain and spinal cord of…
Citation impact
- FWCI
- 47.03
- Percentile
- 100%
- References
- 56
Authors
8- XSX Shen
Sichuan University, Sichuan Provincial Library
- YWYuqing Wang
Sichuan University, West China Hospital of Sichuan University, Sichuan Provincial Library
- YYYi Yang
Stomatological Hospital of Chongqing Medical University, Chongqing Medical University
- BTBicai Tang
Sichuan University, Sichuan Provincial Library
- LBLong Bai
Sichuan University, Sichuan Provincial Library
Topics & keywords
- Nasal administration
- Central nervous system
- Neuroinflammation
- Drug delivery
- Experimental autoimmune encephalomyelitis
- Sting
- Neuron
- Stimulator of interferon genes