Natural diversity of telomere length distributions across 100 Saccharomyces cerevisiae strains
Centre National de la Recherche Scientifique · Inserm · +5 more institutions
Abstract
Telomeres gradually shorten at each cell division, and telomerase counteracts this shortening by elongating telomere sequences. This dynamic balance between elongation and shortening results in a steady-state telomere length (TL) distribution. Here, we develop a method for detecting telomeric sequences in Saccharomyces cerevisiae genomes from raw Oxford Nanopore Technologies (ONT) sequencing reads, providing a comprehensive view of TL distributions both genome-wide and at individual chromosome extremities. We analyze the TL distribution in 100 S. cerevisiae strains, representing the genetic and ecological diversity of the species. Our analysis reveals a large diversity in TL distributions within the species,…
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Authors
7- CGClotilde GarridoCorresponding
Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Biologie Computationnelle, Quantitative et Synthétique, Institut de Biologie Paris-Seine
- CGCintia Gómez-Muñoz
Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Biologie Computationnelle, Quantitative et Synthétique, Institut de Biologie Paris-Seine
- EKEtienne Kornobis
Institut Pasteur, Université Paris Cité
- NANicolas Agier
Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Biologie Computationnelle, Quantitative et Synthétique, Institut de Biologie Paris-Seine
- OIOana Ilioaia
Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Biologie Computationnelle, Quantitative et Synthétique, Institut de Biologie Paris-Seine
Topics & keywords
- Telomere
- Polyploid
- Ploidy
- Subtelomere
- Chromosome
- Genetic diversity
- Genome
- Telomerase
- Life in Land