Early-Life Gut Microbiota: Education of the Immune System and Links to Autoimmune Diseases

Early life is a critical window for immune system development, during which the gut microbiome shapes innate immunity, antigen presentation, and adaptive immune maturation. Disruptions in microbial colonization—driven by factors such as cesarean delivery, antibiotic exposure, and formula feeding—deplete beneficial early-life taxa (e.g., Bifidobacterium, Bacteroides, and Enterococcus) and impair key microbial functions, including short-chain fatty acid (SCFA) production by these keystone species, alongside regulatory T cell induction. These dysbiosis patterns are associated with an increased risk of pediatric autoimmune diseases, notably type 1 diabetes, inflammatory bowel disease, celiac disease, and juvenile…

• Z
  ZonMw

  Awards: 09150182010020, 09150172210050
• DF
  Diabetes Fonds
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Award: 09150172210050