articleCardiovascular DiabetologyJan 17, 2026GOLD OA

Association of cholesterol, high-density lipoprotein and glucose (CHG) index with mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD) adults: results from two prospective cohorts

HZHuangxin ZhuLLLihua LiuSYSicheng YangYFYunfeng FuYPYating Pan

First Affiliated Hospital of Jiangxi Medical College · Chinese Academy of Medical Sciences & Peking Union Medical College · +3 more institutions

PubMed
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Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a health issue of increasing concern worldwide. The cholesterol-high density lipoprotein-glucose (CHG) index integrates key metabolic pathways, but its relationship with the prognosis of MASLD remains unclear. A total of 13,286 MASLD adults were included in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The mortality results were determined by linking to the National Death Index (NDI) records. A weighted Cox model, restricted cubic spline (RCS) and threshold analysis were used to examine the nonlinear relationship between baseline CHG and all-cause (ACM) or cardiovascular mortality (CVM). Subgroup analysis…

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10
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156.47
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100%
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8

Topics & keywords

Topics
Keywords
  • National Death Index
  • Proportional hazards model
  • Waist
  • Subgroup analysis
  • Index (typography)
  • Body mass index
  • Disease
  • Prospective cohort study
UN Sustainable Development Goals
  • Good health and well-being
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