Dietary polyphenols as functional food bioactives: Nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant and immunomodulatory mechanisms in combating bacterial infections
Agriculture and Agri-Food Canada · McGill University
Abstract
The rising threat of antimicrobial resistance (AMR) highlights the need for novel strategies to fight against microbial pathogens while strengthening host defenses. Dietary polyphenols abundant in fruits, vegetables, and food byproducts, could offer dual antimicrobial and host-protective effects. At the same time, nuclear factor erythroid 2-related factor 2 (Nrf2) activation emerges as one of key mechanisms that extend beyond antioxidant control to regulate cytokine production and innate immune signaling. This review discusses the underexplored role of polyphenol in activating Nrf2 as a signaling hub that coordinates host immune responses against bacterial infection. Despite bioavailability hurdles,…
Citation impact
- FWCI
- 40.09
- Percentile
- 99%
- References
- 161
Authors
4Topics & keywords
- Polyphenol
- Immune system
- Antioxidant
- Antimicrobial
- Innate immune system
- Functional food
- Host (biology)
- Zero hunger