Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration
Shanghai Jiao Tong University · National Clinical Research Center for Digestive Diseases · +10 more institutions
Abstract
Abstract Nociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors actively regulate the immune response during bone regeneration remains unclear. Here, we found that neutrophil-triggered nociceptive ingrowth functioned as negative feedback regulation to inflammation during bone healing. A unique Il4ra + Ccl2 high neutrophil subset drove intense postinjury TRPV1 + nociceptive ingrowth, which in return dissipated inflammation by activating the production of pro-resolving mediator lipoxin A4 (LXA4) in osteoblasts. Mechanistically, osteoblastic autophagy activated by nociceptor-derived calcitonin gene-related peptide (CGRP) suppressed the nuclear…
Citation impact
- FWCI
- 72.49
- Percentile
- 100%
- References
- 99
Authors
8- XQXuanyu Qi
Shanghai Jiao Tong University, National Clinical Research Center for Digestive Diseases, Shanghai Stomatological Hospital, Shanghai Ninth People's Hospital
- GYGuangzheng YANG
Shanghai Jiao Tong University, National Clinical Research Center for Digestive Diseases, Shanghai Stomatological Hospital, Shanghai Ninth People's Hospital
- ZXZeqian Xu
Shanghai Jiao Tong University, National Clinical Research Center for Digestive Diseases, Shanghai Stomatological Hospital, Shanghai Ninth People's Hospital
- MFM F Zhou
Shanghai Jiao Tong University, Fudan University, National Clinical Research Center for Digestive Diseases, Shanghai Stomatological Hospital, Shanghai Ninth People's Hospital
- TLTejing Liu
Nanjing Medical University
Topics & keywords
- Nociception
- Inflammation
- Nociceptor
- Mediator
- Regeneration (biology)
- TRPV1
- Agonist
- Bone resorption
- Good health and well-being