Green-synthesized silver-alginate-ciprofloxacin hydrogel: A multifaceted therapeutic for enhanced diabetic and burn Wound healing

Wound healing is a complex physiological process involving coordinated phases of inflammation, tissue repair, and scar formation to restore tissue integrity. Recently, silver nanoparticles (AgNPs) have been investigated for their potential to promote wound healing; however, their application is limited by concerns over cytotoxicity and the development of bacterial resistance. To address these limitations, this study presents the development of a silver-alginate hydrogel (AgSACip) incorporating ciprofloxacin, synthesized using green tea extract act as a biogenic reducing and stabilizing agent. Sodium alginate, a naturally derived macromolecule, serves as a biocompatible matrix to stabilize AgNPs, reduce…