Glycophagy is an ancient bilaterian pathway supporting metabolic adaptation through STBD1 structural evolution
Chinese Academy of Fishery Sciences · Ocean University of China · +3 more institutions
Abstract
Glycophagy, a selective form of autophagy critical for glycogen homeostasis, relies on the glycogen cargo receptor called starch-binding domain-containing protein 1 (STBD1), yet its evolutionary origins remain elusive. Here, we provide evidence that the Pacific oyster Crassostrea gigas utilizes glycophagy to manage glycogen mobilization during periods of energy deprivation. We identify an oyster STBD1 protein, and trace its origins through phylogenetic and comparative genomic analysis of the carbohydrate binding module family 20 (CBM20) domain within this protein across metazoans. Oyster STBD1 and those in other invertebrates contain an N-terminal CBM20, contrasting the C-terminal location of CBM20 in…
Citation impact
- FWCI
- 50.88
- Percentile
- 100%
- References
- 67
Authors
7Topics & keywords
- Vertebrate
- Chordate
- Glycogen
- Phylogenetic tree
- Phylogenetics
- Adaptation (eye)
- Marine invertebrates
- Protein domain
- Life below water
Funding
- NNNational Natural Science Foundation of ChinaAwards: 32341060, XPN-100, 42276112, CARS-49
- OUOcean University of ChinaAward: CARS-49
- ARAgriculture Research System of ChinaAward: CARS-49
- DFDirectorate for Biological Sciences
- KTKey Technology Research and Development Program of ShandongAward: 2021ZLGX03
- NKNational Key Research and Development Program of ChinaAwards: CARS-49, 2022YFD2400300, 2021ZLGX03
- FRFundamental Research Funds for the Central UniversitiesAwards: CARS-49, 202461040