Radical docking–migration: a powerful strategy for difunctionalization of alkenes and alkynes

Radical addition and migration cascades. The scope encompasses various migrating groups, including aryl, heteroaryl, alkynyl, oximino, alkenyl, and imino units, and highlights extensions to challenging unactivated alkenes and alkynes. The mechanistic insights, substrate scope, and synthetic applications of these transformations are discussed, underscoring the potential of the radical docking-migration strategy in modern synthetic chemistry.

• NN
  National Natural Science Foundation of China

  Awards: 22371185, 22171201, 22501184, 22571194
• FR
  Fundamental Research Funds for the Central Universities

  Awards: 24X010301678, 23X010301599
• PO
  Program of Shanghai Academic Research Leader

  Award: 23XD1421900