A prefrontal cortex map based on single-neuron activity
Université Claude Bernard Lyon 1 · Centre National de la Recherche Scientifique · +9 more institutions
Abstract
The intrinsic organization underlying the central cognitive role of the prefrontal cortex (PFC) is poorly understood. We approached organization by profiling the activity and spatial location of >24,000 neurons recorded in awake mice. High-resolution activity maps of the PFC did not align with cytoarchitecturally defined subregions. Instead, spontaneous activity and tuning to choice during a behavioral task were both related to intra-PFC hierarchy, suggesting that connectivity, rather than cytoarchitecture, shapes the PFC's activity landscape. Low-rate, regular spontaneous firing was a hallmark of both the PFC and high hierarchy. Surprisingly, choice tuning was overrepresented in units displaying high…
Citation impact
- FWCI
- 61.95
- Percentile
- 99%
- References
- 50
Authors
10- PLPierre Le MerreCorresponding
Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, Inserm, Karolinska Institutet, Centre de Recherche en Neurosciences de Lyon
- KHKatharina Heining
Karolinska Institutet
- MSMarina Slashcheva
Karolinska Institutet
- FJFelix Jung
Karolinska Institutet
- EMEleni Moysiadou
Centre National de la Recherche Scientifique, Inserm, Institut Pasteur, Karolinska Institutet, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Institut du Cerveau
Topics & keywords
- Prefrontal cortex
- Premovement neuronal activity
- Functional organization
- Cognition
- Functional specialization
- Systems neuroscience
- Brain mapping
- Neural activity