Adjunctive Therapies in Periodontitis: Current Concepts and the Future
Universidade Estadual Paulista (Unesp) · Universidade Tecnológica Federal do Paraná · +7 more institutions
Abstract
Periodontitis is a chronic, host-mediated inflammatory disease in which microbial dysbiosis and dysregulated immune responses drive the destruction of tooth-supporting tissues. Although conventional therapy remains centered on mechanical biofilm control, persistent inflammation and alveolar bone loss in susceptible individuals underscore the need for adjunctive strategies. Translating preclinical discoveries into predictable clinical outcomes, however, remains a major challenge in periodontal research. This narrative review integrates two interrelated themes, translational research methodology and adjunctive therapeutic innovation, to critically examine how preclinical findings can be more effectively bridged…
Citation impact
- FWCI
- 67.28
- Percentile
- 99%
- References
- 197
Authors
5- RSRafael Scaf de MolonCorresponding
Universidade Estadual Paulista (Unesp)
- JPJoão Paulo Steffens
Universidade Tecnológica Federal do Paraná, Universidade Federal do Paraná
- ÉDÉrica Dorigatti de Ávila
Universidade Estadual Paulista (Unesp)
- WTWim Teughels
Chulalongkorn University, University of Malaya, KU Leuven
- TEThomas E. Van Dyke
Harvard University, Somerville Hospital, Institute of Infection and Immunity
Topics & keywords
- Periodontitis
- Translational research
- Adjunctive treatment
- Dysbiosis
- Clinical trial
- Translational science
- Disease
- Translational medicine
- Industry, innovation and infrastructure