Quantum spin resonance in engineered proteins for multimodal sensing

Abrahams, Gabriel; Štuhec, Ana; Spreng, Vincent; Henry, Robin; Kempf, Idris; James, Jessica; Sechkar, Kirill; Stacey, Scott; Trelles-Fernandez, Vicente; Antill, Lewis M.; Timmel, Christiane R.; Miller, Jack J.; Ingaramo, Maria; York, Andrew G.; Tetienne, Jean‐Philippe; Steel, Harrison

doi:10.1038/s41586-025-09971-3

articleNatureJan 21, 2026HYBRID OA

Quantum spin resonance in engineered proteins for multimodal sensing

GAGabriel Abrahams AŠAna Štuhec VSVincent Spreng RHRobin Henry IKIdris Kempf

University of Oxford · Heidelberg University · +5 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Sensing technologies that exploit quantum phenomena for measurement are finding increasing applications across materials, physical and biological sciences 1–7 . Until recently, biological candidates for quantum sensors were limited to in vitro systems, had poor sensitivity and were prone to light-induced degradation. These limitations impeded practical biotechnological applications, and high-throughput study that would facilitate their engineering and optimization. We recently developed a class of magneto-sensitive fluorescent proteins including MagLOV, which overcomes many of these challenges 8 . Here we show that through directed evolution, it is possible to engineer these proteins to alter the…

Citation impact

11

total citations

FWCI: 103.47
Percentile: 100%
References: 71

Too recent for citation history.

Authors

16

Topics & keywords

Topics

Keywords

Quantum sensor
Fluorescence
Quantum
Magnetic resonance imaging
Förster resonance energy transfer
Quantum dot
Magnetic field
Spin (aerodynamics)

No related works found for this paper.