Clinical translation of injectable hydrogels: from bioactive polymers to long-acting drug delivery systems
Center for Research in Molecular Medicine and Chronic Diseases · Madrid Institute for Advanced Studies · +1 more institution
Abstract
Injectable hydrogels (IHs) have emerged as versatile biomaterials that enable localized therapy through minimally invasive delivery. Their in situ sol-gel transition supports sustained and targeted release of therapeutics, enhancing patient comfort and reducing dosing frequency. However, clinical translation remains limited due to challenges in achieving controlled degradation, ensuring long-term biocompatibility, scaling production, and meeting regulatory standards. Despite these hurdles, several IH-based formulations are progressing through clinical trials or have reached the market, underscoring their therapeutic potential. This review examines the major translational barriers and highlights recent advances…
Citation impact
- FWCI
- 56.70
- Percentile
- 100%
- References
- 116
Authors
3- NCNatalia Carballo-Pedrares
Center for Research in Molecular Medicine and Chronic Diseases
- VMVirna Margarita Martín Giménez
Center for Research in Molecular Medicine and Chronic Diseases
- MJMaría José AlonsoCorresponding
Madrid Institute for Advanced Studies, Universidade de Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases
Topics & keywords
- Drug delivery
- Clinical trial
- Translation (biology)
- Clinical Practice
- Self-healing hydrogels
- Drug
- Dosing