Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina
Cedars-Sinai Medical Center · University of California, Los Angeles · +7 more institutions
Abstract
Abstract Chlamydia pneumoniae is an intracellular bacterium implicated in Alzheimer’s disease (AD), but its role in retinal pathology and disease progression is unclear. Here we identify Chlamydia pneumoniae inclusions in the retina, showing higher burden in AD retina and brain, increasing with APOEε4, disease stage, and cognitive deficit. Retinal and cortical proteomics reveal bacterial-infection and related NLRP3-inflammasome pathways. Retinal NLRP3 is elevated in mild cognitive impairment and activated in AD dementia, evidenced by increased caspase-1, cleaved interleukin-1β, and cleaved N-terminal gasdermin-D. Chlamydia pneumoniae associates with amyloid-β 42 , inflammation, apoptosis, pyroptosis, and AD…
Citation impact
- FWCI
- 56.44
- Percentile
- 100%
- References
- 91
Authors
23Topics & keywords
- Chlamydia
- Chlamydophila pneumoniae
- Inflammasome
- Retina
- Retinal
- Chlamydiaceae
- Chlamydiales
- Disease