Cancer stem cell-driven drug resistance in colorectal carcinoma: molecular aspects and therapeutic potentials
Hubei University of Medicine · Union Hospital · +5 more institutions
Abstract
Colorectal cancer (CRC) remains a major global health burden, with therapeutic resistance accounting for the majority of treatment failures and cancer-related deaths. Cancer stem cells (CSCs), which possess intrinsic drug tolerance and self-renewal capacity, drive both primary and acquired resistance. CSCs maintain drug tolerance through the activation of core signaling cascades, including Wnt/β-catenin, Notch, Hedgehog, PI3K/Akt, and MAPK/ERK pathways, as well as through epithelial-mesenchymal transition (EMT), enhanced DNA repair, and PD-1/PD-L1-mediated immune evasion. These molecular alterations transform the tumor microenvironment (TME) into a stemness-supportive, immunosuppressive niche, thereby…
Citation impact
- FWCI
- 62.55
- Percentile
- 100%
- References
- 199
Authors
13- MZMinfeng Zhou
Hubei University of Medicine, Union Hospital, Huazhong University of Science and Technology
- HNHuifang Niu
Jianghan University, China Association of Acupuncture-Moxibustion
- DCDandan Cui
Union Hospital, Huazhong University of Science and Technology
- MXMenghao Xu
Union Hospital, Huazhong University of Science and Technology
- JLJin Li
Union Hospital, Huazhong University of Science and Technology
Topics & keywords
- Cancer stem cell
- Drug resistance
- Epigenetics
- Tumor microenvironment
- Immune checkpoint
- Immune system
- Colorectal cancer
- Cancer
- Good health and well-being