Kinetic Influence of Electrophile‐Alkene Exchange of Nickel‐Alkene Complexes in Oxidative Addition †
Shanghai Institute of Organic Chemistry · University of Chinese Academy of Sciences
Abstract
Comprehensive Summary The oxidative addition of electrophiles to transition metals is a fundamental step in transition‐metal‐mediated cross‐coupling reactions. Although the mechanism of transition‐metal‐enabled C–X bond cleavage has garnered significant attention due to its impact on reaction selectivity and reactivity, the preceding association step between the electrophile and metal has long been underappreciated, particularly with regard to its kinetic effects. Here, we report and validate an associative electrophile‐alkene exchange (E A A) strategy using nickel(0)‐alkene complexes. This approach shifts the rate‐determining step from C–X bond cleavage to electrophile‐alkene exchange. By doing so, it enables…
Citation impact
- FWCI
- 32.37
- Percentile
- 99%
- References
- 72
Authors
3Topics & keywords
- Electrophile
- Oxidative addition
- Catalysis
- Bond cleavage
- Alkene
- Reactivity (psychology)
- Selectivity
- Ligand (biochemistry)