Timeshare surface-enhanced Raman scattering platform with sensitive and quantitative mode

The sensitivity and quantification capability of surface-enhanced Raman scattering (SERS) substrates are mutually exclusive, because the ultrasensitive SERS sites (hottest spots) necessary for the sensitivity will significantly magnify the SERS signals of the analyte molecules and thus each of these molecules will be miscounted to be hundreds during the quantification process. We demonstrate a concept to circumvent the above contradiction by engineering a timeshare SERS platform capable of working at the quantitative or the sensitive mode on demand. The timeshare SERS platform was constructed by transferring a monolayer gold nanosphere film onto elastic substrates (e.g., hydrogel). The volume change of the…

• NS
  National Science Foundation
• NN
  National Natural Science Foundation of China

  Awards: 12304422, 52273233
• CP
  China Postdoctoral Science Foundation
• GO
  Government of Jiangsu Province
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20230911
• NS
  Natural Science Foundation of Inner Mongolia