Centrosome Transplantation

The centrosome, a key microtubule-organizing center, has long been implicated in fundamental cellular processes such as division, polarity, and ciliogenesis. Observations linking centrosomal aberrations to specific cellular states, including senescence and aging, raise a pivotal question: is the centrosome merely a structural casualty of these states, or does it actively encode and transmit information dictating cellular phenotype? This article explores the conceptual framework, methodology, and profound implications of centrosome transplantation, an experimental paradigm designed to answer this question by directly testing causality. We review the historical context of organelle transplantation, detail a…