Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial

Abstract Objective To test the hypothesis that women assigned to a natural ovulation regimen before frozen embryo transfer compared with a programmed regimen would have an increased chance of a healthy live birth and a reduced risk of pre-eclampsia or eclampsia. Design Multicentre, randomised, parallel group, assessor blinded clinical trial. Setting 24 academic fertility centres in China. Participants 4376 ovulatory women (aged 20-40 years) planning to undergo a frozen single blastocyst transfer. Interventions Eligible participants were randomised (1:1) to receive a natural ovulation regimen or a programmed regimen of hormone replacement for endometrial preparation. Endometrial preparation and frozen embryo…

• NN
  National Natural Science Foundation of China

  Awards: 82421004, 32588201