Dissecting gene regulatory networks governing human cortical cell fate
University of California, San Francisco · Broad Center · +1 more institution
Abstract
Abstract Human cortical neurogenesis involves conserved and specialized developmental processes during a restricted window of prenatal development. Radial glia (RG) neural stem cells shape cortical cell diversity by giving rise to excitatory neurons, oligodendrocytes and astrocytes, as well as olfactory bulb interneurons (INs) and a recently characterized population of cortical INs 1,2 . Complex genetic programs orchestrated by transcription factor (TF) circuits govern the balance between self-renewal and differentiation, and between different cell fates 3–8 . Despite progress in measuring gene regulatory network activity during human cortical development 9–12 , functional studies are required to evaluate the…
Citation impact
- FWCI
- 41.23
- Percentile
- 99%
- References
- 132
Authors
9- JWJingwen W. DingCorresponding
University of California, San Francisco, Broad Center
- CKC. Kim
University of California, San Francisco, Neurological Surgery
- MSMegan S Ostrowski
University of California, San Francisco, Broad Center
- YAYashodara Abeykoon
University of California, San Francisco, Broad Center
- BJBryan J. Pavlovic
University of California, San Francisco, Broad Center
Topics & keywords
- Cell fate determination
- Neurogenesis
- Gene regulatory network
- Transcription factor
- Effector
- Neural stem cell
- Olfactory bulb
- Population
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