Artificial Intelligence Drives Advances in Multi-Omics Analysis and Precision Medicine for Sepsis

Sepsis is a life-threatening syndrome characterized by marked clinical heterogeneity and complex host-pathogen interactions. Although traditional mechanistic studies have identified key molecular pathways, they remain insufficient to capture the highly dynamic, multifactorial, and systems-level nature of this condition. The advent of high-throughput omics technologies-particularly integrative multi-omics approaches encompassing genomics, transcriptomics, proteomics, and metabolomics-has profoundly reshaped sepsis research by enabling comprehensive profiling of molecular perturbations across biological layers. However, the unprecedented scale, dimensionality, and heterogeneity of multi-omics datasets exceed the…