Beyond the Multicomponent Debus–Radziszewski Route: Two-Component Cyclocondensation Constructing a 12 + 3-Connected aea Topology Three-Dimensional Imidazole-Linked COF for Sustainable Wastewater Treatment

The rational construction of high-connectivity three-dimensional covalent organic frameworks (3D COFs) remains a central challenge in reticular chemistry, holding immense promise for advancing framework rigidity, porosity, and functional integration. From both fundamental and application standpoints, diversifying the linkage chemistry of such high-connectivity COFs beyond the archetypal imine bond is essential, as imidazole linkages impart superior chemical resilience, enhanced π-delocalization, and intrinsic polarity compared with imine linkages. Here, we report TU-123, the first 12 + 3-connected 3D imidazole-linked COF with aea topology, synthesized via a two-component cyclocondensation between a…

• MO
  Ministry of Education, Culture, Sports, Science and Technology

  Award: JPMXP1225TU1067
• YM
  Yazaki Memorial Foundation for Science and Technology
• JS
  Japan Society for the Promotion of Science

  Awards: 23KK0098, 23H00289