articleOrganic LettersJan 22, 2026Closed access

Phosphonium Ylide-Catalyzed Z -Stereoselective Synthesis of α-Substituted Monofluoroalkenes from gem -Difluoroalkenes and Triazoles

MGMinhui GuanYNYulong NiuJSJiayuan ShuiHCH. ChenLWLei Wang

Taizhou University

PubMed
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Abstract

-difluoroalkenes and triazoles. The reaction is promoted with high stereoselectivity and compatible with a broad range of substrates. A wide range of complex natural products and pharmaceuticals are amenable to late-stage modification. Experimental mechanistic studies indicate that the phosphonium cation, formed via capture of the N-protecting group of triazole by the phosphine ylide, may play a key role in governing stereoselectivity.

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Topics & keywords

Topics
Keywords
  • Phosphonium
  • Phosphine
  • Ylide
  • Stereoselectivity
  • Catalysis
  • Surface modification
  • Total synthesis
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