articleResearchJan 1, 2026GOLD OA

The Brain–Gut Health Initiative (BIGHI): A Prospective Cohort on Psychiatric Disorders in China

KWKai WuBZBaoyuan ZhuSFShixuan FengHLHehua LiJZJing Zhou

Guangzhou Psychiatric Hospital · Guangdong 999 Brain Hospital · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Major psychiatric disorders are characterized by substantial clinical heterogeneity and high comorbidity, yet their underlying biological mechanisms are not fully uncovered. The microbiota-gut-brain axis (MGBA) offers a cross-system perspective for elucidating the pathophysiology of major psychiatric disorders. The Brain-Gut Health Initiative (BIGHI) was established as the first prospective longitudinal cohort in China dedicated to investigating major psychiatric disorders guided by the framework of MGBA, enabling large-scale, transdiagnostic, and longitudinal analyses of brain-gut interactions. To date, the BIGHI has enrolled over 1,200 participants with schizophrenia, major depressive disorder, bipolar…

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5
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59.65
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100%
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Topics & keywords

Topics
Keywords
  • Neurocognitive
  • Prospective cohort study
  • Cohort
  • Depression (economics)
  • Mental health
  • Bipolar disorder
  • Cohort study
  • Major depressive disorder
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