articleRSC AdvancesJan 1, 2026GOLD OA

Self-assembling nanocomposites for smart drug delivery: towards personalized and stimuli-responsive therapeutics

University of Tehran · North Khorasan University of Medical Sciences · +4 more institutions

PubMed
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Abstract

Self-assembling nanocomposites (SANCs) represent a valuable and innovative drug delivery system that facilitates site-specific and stimulus-controlled drug administration. These composites have the capability to self-assemble into stimulus-responsive nanostructures, enabling the effective delivery of a wide range of therapeutic agents, from small molecules to biologics, to specific target sites. This advancement addresses crucial challenges in treating diseases like cancer and chronic inflammatory conditions. In this review, we briefly outline the advantages of SANCs in enhancing bioavailability, reducing systemic toxicity, and maintaining stability under physiological conditions. However, several significant…

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