articleJournal of EthnopharmacologyJan 23, 2026HYBRID OA

Study on the mechanism of anti-pulmonary fibrosis action of Jingfang granules based on the Keap1-Nrf2-GPX4 pathway

WYWenjing YuYCYonghu ChenHCHongzhen ChenZJZhen JiangJYJingChun Yao

Yanbian University · Luye Pharma (China)

PubMed
Indexed incrossrefpubmed

Abstract

Jingfang granules (JF) is derived from the original formula of Jingfang Baidu Powder. Modern pharmacological studies have shown its antipyretic, analgesic, and anti-inflammatory effects. It has been clinically used to treat viral respiratory infections and human mycoplasma pneumonia, with proven efficacy and significant improvement in patients' clinical symptoms. However, the mechanism by which JF treats pulmonary fibrosis (PF) remains unclear. This study aims to investigate the therapeutic efficacy of JF in PF and elucidate its potential therapeutic mechanisms. To explore the therapeutic potential of JF in PF, we constructed a mouse model of PF induced by bleomycin (BLM) and an integrated in vitro co-culture…

Citation impact

5
total citations
FWCI
45.66
Percentile
100%
References
41
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Authors

8

Topics & keywords

Topics
Keywords
  • Mechanism of action
  • Mechanism (biology)
  • Fibrosis
  • Action (physics)
  • Signal transduction
  • Chromosomal translocation
  • Drug
UN Sustainable Development Goals
  • Good health and well-being
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