Centriole Biogenesis Disruption Impairs Regenerative Patterning in Planarians

Centrioles are classically known for their role in mitotic spindle formation, yet their broader function in complex tissue regeneration remains poorly defined. Using the planarian Schmidtea mediterranea as a model, this review synthesizes findings from recent studies employing targeted RNAi and pharmacological inhibition to disrupt centriole biogenesis during pharyngeal regeneration. The analysis reveals that centrioles are indispensable, multi-functional organelles governing a hierarchical cascade of regenerative events. Complete inhibition of centriole duplication (e.g., via Plk4 or SAS-6 knockdown) abolishes neoblast proliferation, preventing blastema formation. Partial impairment of centriolar function…