Nanozyme for precision treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) remains a formidable challenge due to profound heterogeneity, recurrence, and pervasive therapeutic resistance, creating a significant unmet clinical need. Engineered nanozymes, nanomaterials with intrinsic catalytic activities, have emerged as a transformative paradigm. Unlike passive nanocarriers, nanozymes function as active therapeutic agents. Their prowess is predicated on catalytically manipulating the tumor microenvironment (TME), enabling localized ROS generation, inducing regulated cell death, and remodeling the immunosuppressive TME. This review systematically delineates the principles and potential of nanozyme strategies for HCC, focusing on catalytic therapy,…

• NN
  National Natural Science Foundation of China

  Award: 82308669
• NS
  Natural Science Foundation of Liaoning Province

  Award: 20242108
• CM
  China Medical University

  Award: CMU-A-2505