Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity
University of California, Berkeley · Molecular Sciences Institute
Abstract
A burgeoning approach to treating cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting antiferroptotic pathways in the broader tumor microenvironment (TME), such as in immune cells, is still undefined and may complicate treatments. Here, we show that ferroptosis suppressor protein 1 (FSP1 /Aifm2 ) is critically required for regulatory T cell (T reg cell) resistance to ferroptosis and their immunosuppressive function within the TME. Compared to other canonical ferroptosis regulators such as GPX4 and NRF2, only FSP1 was induced upon T cell activation. Deletion of Aifm2 in all T cells, or T reg cells specifically, enhanced tumor control by selectively…
Citation impact
- FWCI
- 63.43
- Percentile
- 99%
- References
- 61
Authors
10Topics & keywords
- Immune system
- Tumor microenvironment
- T cell
- Regulator
- Cancer cell
- Immunosuppression
- GPX4
- Immunity
- Good health and well-being