Self‐Assembled Ruthenium Complexes With Sonobleaching Ligand for Enhanced Tumor Penetration and Immunogenic Sonotherapy
Dalian University of Technology · Dalian University
Abstract
Ruthenium complexes, which can be activated with precise light-induced spatiotemporal control, are recognized as promising candidates for cancer therapy. However, the inadequate tumor penetration and their dependence on light activation present challenges to deeper clinical application. Herein, we introduce a charge-reversal strategy to enhance tumor penetration and cellular uptake of RuIR783, a self-assembled metalloprodrug activated by ultrasound, thereby enabling deep tissue penetration. RuIR783 is synthesized by coordinating a Ru(II) polypyridyl complex with a heptamethine cyanine dye bearing two hydrophilic sulfonic groups. The cyanine dye component serves as both the ultrasound antenna and the…
Citation impact
- FWCI
- 41.32
- Percentile
- 100%
- References
- 63
Authors
10- MHMaomao He
Dalian University of Technology, Dalian University
- XCXitong Cheng
Dalian University of Technology, Dalian University
- LZLinhao Zhang
Dalian University of Technology, Dalian University
- ZZZongwei Zhang
Dalian University of Technology, Dalian University
- CLChaogan Liu
Dalian University of Technology, Dalian University
Topics & keywords
- Cyanine
- Internalization
- Ruthenium
- Singlet oxygen
- Penetration (warfare)
- HeLa
- Nanoparticle
- Ligand (biochemistry)
- Good health and well-being